Colostrum and Preterm Babies: A Systematic Review

Colostrum from mothers is rich in immunomodulating bio-factors such as immunoglobulins (IgA), lactoferrin, and oligosaccharides supports gut microbial inflammatory processes. The support these processes may provide some relief for infants who are born pre-term. Pre-term more likely to develop necrotizing enterocolitis (NEC), late-onset sepsis (LOS), ventilator-acquired/associated pneumonia (VAP). Due the components of colostrum, there be incentives towards early administration preterm infants. An extensive literature review was done using ProQuest, ScienceDirect, PubMed. Only meta-analyses experimental studies were used. search included keywords ‘colostrum preterm’ enterocolitis’. initial generated 13,543 articles narrowed 25 through comprehensive inclusion exclusion criteria. There significantly higher levels Lactobacillus Bifidobacterium pre-term given colostrum a decrease Moraxellaceae Staphylococcaceae. Salivary secretory IgA increased following oral along with downregulation interleukin (IL)-1b IL-8. It also observed that tumor necrosis factor (TNF)-a, interferon-gamma (IFN-g) control group. no significant difference incidence LOS, NEC, or VAP between receiving those did not. Secondary outcomes time full enteral feeding improved addition reduced hospital stays. Lastly, mortality received compared